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Not only its volume but will also the purposeful properties of Hb have an impact on efficiency. That is illustrated from the observation that an elevated Hb-O2 affinity favors O2 loading in the lung and survival in an hypoxic environment (Eaton et al., 1974; Hebbel et al., 1978), Whilst a lessened Hb-O2 affinity favors the release of O2 from the Hb